NCIt definition : A non-fucosylated monoclonal antibody directed against the ephrin receptor A3 (EphA3),
with potential antineoplastic activity. Upon administration, ifabotuzumab selectively
binds to tumor cells expressing EphA3. This blocks both EphA3 activation and EphA3-mediated
signaling, and induces apoptosis in EphA3-expressing tumor cells. In addition, ifabotuzumab
can stimulate antibody dependent cell-mediated cytotoxicity (ADCC) against EphA3-expressing
tumor cells. This agent also prevents tumor cell proliferation by inhibiting both
EphA3 signaling and proliferation of endothelial cells in the tumor vasculature. The
cell-surface receptor EphA3, a member of the ephrin family of receptor tyrosine kinases
(RTKs) that are involved in mammalian development, is overexpressed by a variety of
tumor types but is not expressed in normal healthy adult tissues. It plays an important
role in tumor cell proliferation. Non-fucosylation of the antibody enhances its ADCC
activity.;