Netrin Receptor DCC

Preferred Label : Netrin Receptor DCC;

NCIt synonyms : Deleted in Colorectal Carcinoma Protein; DCC; CRC18; Colorectal Cancer Suppressor; Tumor Suppressor Protein DCC; Immunoglobulin Superfamily DCC Subclass Member 1; DCC Protein; Colorectal Tumor Suppressor;

NCIt definition : Netrin receptor DCC (1447 aa, 158 kDa) is encoded by the human DCC gene. This protein is involved in both axonal guidance and the regulation of apoptosis.;

NCIt note : Netrin receptor DCC is a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Knockout studies in mice failed to support a tumor-suppressor function for DCC in the mouse, but were consistent with the hypothesis that DCC is a component of the receptor for netrin-1, a neuronal chemoattractant. (from OMIM);

Details

Origin ID

C17908;

UMLS CUI

C1259909;

OMIM relation
- Dcc netrin 1 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DCC protein, human [MeSH concept]
- DCC protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DCC Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Intestine [NCIt concept]
- Nervous System [NCIt concept]
gene_product_has_associated_anatomy
- Axon [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Immunoglobulin Family Protein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Ligand Binding [NCIt concept]
- Neural Development [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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