Ephrin Type-A Receptor 4

Preferred Label : Ephrin Type-A Receptor 4;

NCIt synonyms : EPHA4; EC 2.7.1.112; EPH-Related Receptor Tyrosine Kinase A4; Ephrin Receptor-EphA4; Receptor Protein-Tyrosine Kinase HEK8; Tyrosine-Protein Kinase Receptor SEK; TYRO1 Protein Tyrosine Kinase; EC 2.7.10.1; Tyrosine-Protein Kinase TYRO1; EPH-Like Kinase 8; hEK8; EK8; Ephrin Receptor EphA4;

NCIt definition : Ephrin type-A receptor 4 (986 aa, 110 kDa) is encoded by the human EPHA4 gene. This protein plays a role in neuronal morphology, cell-cell signaling, tyrosine phosphorylation and the regulation of GTPase activity.;

NCIt note : The signaling pathways downstream of ephrin receptors are referred to as forward signaling while the signaling pathways downstream of the ephrin ligands are referred to as reverse signaling. (UniProt);

Details

Origin ID

C26159;

UMLS CUI

C1333408;

OMIM relation
- Ephrin receptor epha4 [OMIM gene]
Semantic type(s)
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- EPHA4 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- EPHA4 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- EphA Receptor Family [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Ephrin A Forward Signaling Pathway [NCIt concept]
- Platelet Aggregation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Nervous System Development [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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