Neuropilin-1 - CISMeF

Preferred Label : Neuropilin-1;

NCIt synonyms : VEGF165R; Vascular Endothelial Cell Growth Factor 165 Receptor; NRP; NRP1; CD304 Antigen; Blood Dendritic Cell Antigen 4; Vascular Endothelial Cell Growth Factor-165 Receptor; Neuropilin-1 Protein;

NCIt definition : Neuropilin-1 (923 aa, 103 kDa) is encoded by the human NRP1 gene. This protein is involved in growth factor-mediated signaling.;

NCIt note : Neuropilin-1 contains 1 MAM, 2 F5/8 type C, and 2 CUB domains and binds to semaphorin 3A, PLGF-2, VEGF-165, and VEGF-B. Isoform 1 appears to mediate chemorepulsion by semaphorins, to increase VEGF-165 binding to KDR, and to regulate VEGF-induced angiogenesis. Expressed in hepatocytes and kidney distal/proximal tubules, secreted 644-aa isoform 2 may bind semaphorins and induce apoptosis by sequestering VEGF-165; it has an adverse effect on blood vessel integrity. Expression of isoforms 1 and 2 does not seem to overlap.; Protein_Plays_Role_In_Biological_Process: Cardiovascular Development;

Details

Origin ID

C33981;

UMLS CUI

C4281812;

Currated CISMeF NLP mapping
- Neuropilin-1 [MeSH concept]
- neuropilin-1 [MeSH Descriptor]
OMIM relation
- Neuropilin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- NRP1 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Apoptosis [NCIt concept]
- Ligand Binding [NCIt concept]
- Neural Development [NCIt concept]
- Organogenesis [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-NRP1 Antibody ASP1948 [NCIt concept]
- DLK1/EPHA2/HBB/NRP1/RGS5/TEM1 Peptide-pulsed Alpha-type-1 Polarized Dendritic Cell Vaccine [NCIt concept]
- Vesencumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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