" /> Neuropilin-1 - CISMeF





Preferred Label : Neuropilin-1;

NCIt synonyms : VEGF165R; Vascular Endothelial Cell Growth Factor 165 Receptor; NRP; NRP1; CD304 Antigen; Blood Dendritic Cell Antigen 4; Vascular Endothelial Cell Growth Factor-165 Receptor; Neuropilin-1 Protein;

NCIt definition : Neuropilin-1 (923 aa, 103 kDa) is encoded by the human NRP1 gene. This protein is involved in growth factor-mediated signaling.;

NCIt note : Neuropilin-1 contains 1 MAM, 2 F5/8 type C, and 2 CUB domains and binds to semaphorin 3A, PLGF-2, VEGF-165, and VEGF-B. Isoform 1 appears to mediate chemorepulsion by semaphorins, to increase VEGF-165 binding to KDR, and to regulate VEGF-induced angiogenesis. Expressed in hepatocytes and kidney distal/proximal tubules, secreted 644-aa isoform 2 may bind semaphorins and induce apoptosis by sequestering VEGF-165; it has an adverse effect on blood vessel integrity. Expression of isoforms 1 and 2 does not seem to overlap.; Protein_Plays_Role_In_Biological_Process: Cardiovascular Development;

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30/05/2025


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