B-Cell Lymphoma/Leukemia 10

Preferred Label : B-Cell Lymphoma/Leukemia 10;

NCIt synonyms : Cellular-E10; mE10; CED-3/ICH-1 Prodomain Homologous E10-Like Regulator; BCL10; Mammalian CARD-Containing Adapter Molecule E10; hCLAP; CARD-Containing Proapoptotic Protein; c-E10; CIPER; cCARMEN; Caspase-Recruiting Domain-Containing Protein; CARD-Like Apoptotic Protein; B-Cell CLL/Lymphoma 10; CARD-Containing Molecule Enhancing NF-Kappa-B; Cellular Homolog of vCARMEN; Bcl-10; B-Cell CLL Lymphoma-10;

NCIt definition : B-cell lymphoma/leukemia 10 (233 aa, 26 kDa) is encoded by the human BCL10 gene. This protein is involved in both the promotion of apoptosis and the activation of nuclear factor-kappa-B signaling.;

NCIt note : The gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. (LocusLink);

Details

Origin ID

C26153;

UMLS CUI

C0766164;

Currated CISMeF NLP mapping
- BCL10 protein, human [MeSH concept]
- BCL10 protein, human [MeSH Supplementary Concept]
False automatic mappings
- cysteine isopropyl ester [MeSH concept]
- cysteine isopropyl ester [MeSH Supplementary Concept]
OMIM relation
- B-cell cll/lymphoma 10 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BCL10 protein, human [MeSH concept]
- BCL10 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BCL10 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Canonical NF-kappaB Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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