" /> BCL10 wt Allele - CISMeF





Preferred Label : BCL10 wt Allele;

NCIt synonyms : c-E10; B-Cell CLL/Lymphoma 10 wt Allele; CIPER; CARMEN; mE10; CLAP;

NCIt definition : Human BCL10 wild-type allele is located in the vicinity of 1p22 and is approximately 12 kb in length. This allele, which encodes B-cell lymphoma/leukemia 10 protein, is involved in the induction of apoptosis and the activation of NF-kappaB.;

NCIt note : BCL10 was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. MALT1 and B-cell lymphoma/leukemia 10 protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.;

GenBank Accession Number : NM_003921;

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12/05/2024


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