Vasopressin V1B Receptor

Preferred Label : Vasopressin V1B Receptor;

NCIt synonyms : Pituitary Vasopressin Receptor 3; Antidiuretic Hormone Receptor 1B; Arginine Vasopressin Receptor 3; AVPR1B; Arginine Vasopressin Receptor 1B; AVPR V1b; Arginine Vasopressin Receptor-1B; V1bR; AVPR V3;

NCIt definition : Vasopressin V1b receptor (424 aa, 47 kDa) is encoded by the human AVPR1B gene. This protein plays a role in G protein-coupled receptor signaling mediated by vasopressin.;

NCIt note : This protein acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.;

Details

Origin ID

C26097;

UMLS CUI

C3849896;

Currated CISMeF NLP mapping
- vasopressin V1b receptor [MeSH concept]
OMIM relation
- Arginine vasopressin receptor 1b [OMIM gene]
Semantic type(s)
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- AVPR1b protein, human [MeSH concept]
- AVPR1b protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- AVPR1B Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Protein Hormone Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Phospholipase C Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Signaling [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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