Platelet-Derived Growth Factor C

Preferred Label : Platelet-Derived Growth Factor C;

NCIt synonyms : SCDGF; PDGFC; PDGF-C; Fallotein; Secretory Growth Factor-Like Protein; Spinal Cord-Derived Growth Factor; VEGF-E;

NCIt definition : Platelet-derived growth factor C (345 aa, 39 kDa) is encoded by the human PDGFC gene. This protein plays a role in both growth factor receptor binding and embryonic development.;

NCIt note : Proteolytic removal of the N-terminal CUB domain, by plasmin or tissue-type plasminogen activator, is required to expose the receptor-binding sequences of platelet-derived growth factor C. (UniProt);

Details

Origin ID

C104751;

UMLS CUI

C1571527;

Automatic exact mappings (from CISMeF team)
- Platelet-derived growth factor C [OMIM gene]
- Vascular endothelial growth factor [LOINC component]
- Vascular endothelial growth factor a [OMIM gene]
- platelet-derived growth factor [MeSH Descriptor]
- platelet-derived growth factor C [MeSH Supplementary Concept]
- platelet-derived growth factor C [MeSH concept]
- vascular endothelial growth factor a [MeSH Descriptor]
- vascular endothelial growth factors [MeSH Descriptor]
OMIM relation
- Platelet-derived growth factor C [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PDGFC protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- PDGFC Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Platelet-Derived Growth Factor [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients