D(1A) Dopamine Receptor

Preferred Label : D(1A) Dopamine Receptor;

NCIt synonyms : DRD1; Dopamine D1 Receptor; Dopamine Receptor D1A; Dopamine Receptor D1; Dopamine Receptor-D1;

NCIt definition : D(1A) dopamine receptor (446 aa, 49 kDa) is encoded by the human DRD1 gene. This protein is involved in neurotransmitter-dependent G protein-coupled receptor signaling.;

NCIt note : Dopamine Receptor D1, encoded by the human DRD1 gene, is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It regulates neuronal growth and development, mediates some behavioral responses, and modulates dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.;

Details

Origin ID

C26120;

UMLS CUI

C3711530;

Currated CISMeF NLP mapping
- receptors, dopamine D1 [MeSH concept]
- receptors, dopamine d1 [MeSH Descriptor]
OMIM relation
- Dopamine receptor d1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- DRD1 protein, human [MeSH concept]
- DRD1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- DRD1 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Central Nervous System [NCIt concept]
- Seminal Vesicle [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- CK1/CDK5 Regulation Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Parkinson's Disease Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Signaling [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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