Protein Kinase A

Preferred Label : Protein Kinase A;

NCIt synonyms : PKA; cAMP-Dependent Protein Kinase; Protein Kinase-A;

NCIt definition : Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/Thr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homo- or heterodimeric regulatory subunits associated with two catalytic subunits. cAMP causes dissociation of inactive holoenzyme into a cAMP-bound dimer of regulatory subunits and two free monomeric catalytic subunits that phosphorylate many cytoplasmic and nuclear substrates. In human, regulatory PRKAR1A, PRKAR1B, PRKAR2A, and PRKAR2B subunits and catalytic PRKACA, PRKACB, and PRKACG subunits have been identified. (NCI);

Details

Origin ID

C16479;

UMLS CUI

C5441746;

Automatic exact mappings (from CISMeF team)
- Protein kinase [LOINC component]
- Protein kinase (substance) [SNOMED CT concept]
- cAMP-dependent protein kinase activity [GO term]
- cAMP-dependent protein kinase complex [GO term]
- mitogen-activated protein kinase kinase 6 [HGNC gene]
- protein kinase [SNOMED Notion]
- protein kinases [MeSH Descriptor]
- protein kinases [MeSH concept]
- protein serine/threonine kinase activity [GO term]
Currated CISMeF NLP mapping
- cyclic AMP-Dependent protein kinases [MeSH Descriptor]
- cyclic AMP-Dependent protein kinases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- cyclic AMP-Dependent protein kinases [MeSH concept]
- cyclic AMP-Dependent protein kinases [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Serine/Threonine Protein Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
has_gene_product_element
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
- cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit [NCIt concept]
- cAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit [NCIt concept]

Keyword's position in hierarchy(ies) :

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