Preferred Label : Taste Transduction Pathway;
NCIt related terms : Taste transduction;
Alternative definition : KEGG: All taste pathways are proposed to converge on common elements that mediate
a rise in intracellular Ca2 followed by neurotransmitter release. Na salt depolarizes
taste cells by passive influx of Na through the amiloride-sensitive Na channel (ENaC).
Acids depolarize taste cells by a variety of mechanisms, including influx of protons
(H ) through ENaC and a proton-gated cation channel (MDEG). Two putative umami receptors
have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4
and the heterodimer, T1R1 T1R3. Umami receptors are coupled to a signaling pathway
involving activation of PLCbeta2, production of IP3 and diacylglycerol, release of
Ca2 from intracellular stores and activation of a transient receptor potential channel,
TRPM5. Bitter compounds, such as denatonium and PROP, activate particular T2R/TRB
isoforms, which activate gustducin heterotrimers. Activated alpha-gustducin stimulates
PDE to hydrolyze cAMP, whereas betagamma subunits activate PLCbeta2 to generate IP3,
which leads to release of Ca2 from internal stores. Artificial sweeteners activate
GPCRs (T1R heterodimers) apparently linked via PLC to IP3 production and release of
Ca2 from intracellular stores. Sugars apparently activate GPCRs linked via AC to
cAMP production which, in turn, may inhibit basolateral K channels through phosphorylation
by cAMP-activated protein kinase A (PKA).;
KEGG ID : hsa04742;
Origin ID : C91453;
UMLS CUI : C2984266;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element