Taste Transduction Pathway

Preferred Label : Taste Transduction Pathway;

NCIt related terms : Taste transduction;

Alternative definition : KEGG: All taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2 followed by neurotransmitter release. Na salt depolarizes taste cells by passive influx of Na through the amiloride-sensitive Na channel (ENaC). Acids depolarize taste cells by a variety of mechanisms, including influx of protons (H ) through ENaC and a proton-gated cation channel (MDEG). Two putative umami receptors have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4 and the heterodimer, T1R1 T1R3. Umami receptors are coupled to a signaling pathway involving activation of PLCbeta2, production of IP3 and diacylglycerol, release of Ca2 from intracellular stores and activation of a transient receptor potential channel, TRPM5. Bitter compounds, such as denatonium and PROP, activate particular T2R/TRB isoforms, which activate gustducin heterotrimers. Activated alpha-gustducin stimulates PDE to hydrolyze cAMP, whereas betagamma subunits activate PLCbeta2 to generate IP3, which leads to release of Ca2 from internal stores. Artificial sweeteners activate GPCRs (T1R heterodimers) apparently linked via PLC to IP3 production and release of Ca2 from intracellular stores. Sugars apparently activate GPCRs linked via AC to cAMP production which, in turn, may inhibit basolateral K channels through phosphorylation by cAMP-activated protein kinase A (PKA).;

KEGG ID : hsa04742;

Details

Origin ID

C91453;

UMLS CUI

C2984266;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 5-Hydroxytryptamine Receptor 1B [NCIt concept]
- Acid-Sensing Ion Channel 2 [NCIt concept]
- Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 [NCIt concept]
- Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3 [NCIt concept]
- Metabotropic Glutamate Receptor 4 [NCIt concept]
- Muscarinic Acetylcholine Receptor M3 [NCIt concept]
- Sodium Channel Protein Type 9 Subunit Alpha [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C [NCIt concept]
- Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1A [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ASIC2 wt Allele [NCIt concept]
- CACNA1A wt Allele [NCIt concept]
- CACNA1C wt Allele [NCIt concept]
- CHRM3 wt Allele [NCIt concept]
- GABRA1 wt Allele [NCIt concept]
- GABRA6 wt Allele [NCIt concept]
- GNB3 wt Allele [NCIt concept]
- GRM4 wt Allele [NCIt concept]
- HTR1B wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- SCN9A wt Allele [NCIt concept]

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