Preferred Label : CSK Protein Kinase Activation Pathway;
NCIt related terms : Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the
T Cell Receptor;
Alternative definition : BIOCARTA: Interaction of T cell receptor with specific antigen in the context of MHC
II activates a signal transduction pathway that leads to T cell activation. In the
T cell receptor signaling pathway, the src family kinases Lck and Fyn are activated
to phosphorylate proteins in the T cell receptor complex which recruit and activate
the ZAP70 kinase. The activation of ZAP70 phosphorylates downstream targets that activate
MAP kinase pathways and cause T cell activation. The CD45 phosphorylase also plays
a role in T cell receptor signaling, dephosphorylated Lck and Fyn to activate them.
Other factors modulate T cell receptor activation. Csk (COOH-terminal Src kinase)
phosphorylates Lck and deactivates it, opposing the action of CD45. The phosphorylation
of Lck by Csk inhibits T cell receptor signaling and inhibits T cell activation. Csk
activity is regulated in T cells by PKA, the cAMP-dependent protein kinase activated
by the second messenger cAMP. The activity of Csk also appears to depend on other
factors such as CBP, which recruits Csk to the plasma membrane in lipid rafts where
other signaling factors such the T cell receptor complex are localized. CBP also directly
activates Csk. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_CSKPathway;
Origin ID : C39038;
UMLS CUI : C1511457;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element