" /> CXCR5 wt Allele - CISMeF





Preferred Label : CXCR5 wt Allele;

NCIt synonyms : BLR1 wt Allele; MDR15; BLR1; CXCR-5; Chemokine (C-X-C Motif) Receptor 5 wt Allele; CD185; Chemokine, C-X-C Motif, Receptor 5 Gene; Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C motif) Receptor 5) Gene;

NCIt definition : Human CXCR5 wild-type allele is located in the vicinity of 11q23.3 and is approximately 12 kb in length. This allele, which encodes C-X-C chemokine receptor type 5 protein, plays a role in B cell migration and localization within specific anatomic locations.;

NCIt note : This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein-coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse counterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist.;

GenBank Accession Number : NM_001716;

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19/05/2024


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