" /> CX3CR1 wt Allele - CISMeF





Preferred Label : CX3CR1 wt Allele;

NCIt synonyms : V28; GPR13; GPRV28; CMKDR1; CMKBRL1; Chemokine (C-X3-C Motif) Receptor 1 wt Allele; CCRL1;

NCIt definition : Human CX3CR1 wild-type allele is located in the vicinity of 3p22.2 and is approximately 18 kb in length. This allele, which encodes CX3C chemokine receptor 1 protein, plays a role in leukocyte endothelial trafficking.;

NCIt note : Up-regulated by chronic inflammation and expressed in brain, peripheral blood leukocytes, and spleen, the intronless 16.5-kb human CX3CR1 Gene (CCR Family, Rhodopsin Family) at 3p21.3 produces a 3.2-kb transcript that encodes a seven transmembrane high-affinity Fractalkine Receptor, a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration and contains common GPCR features. CX3CR1 may be an HIV envelope protein co-receptor with CD4.;

GenBank Accession Number : NM_001337;

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30/04/2024


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