Preferred Label : XCL1 wt Allele;
NCIt synonyms : SCYC1; SCM1; LTN; LPTN; ATAC; SCM-1a; Chemokine (C Motif) Ligand 1 wt Allele; SCM-1; SCM1A; Small Inducible Cytokine Subfamily C, Member 1 (Lymphotactin) Gene;
NCIt definition : Human XCL1 wild-type allele is located in the vicinity of 1q23 and is approximately
5 kb in length. This allele, which encodes lymphotactin protein, is involved in lymphocyte
trafficking and inflammatory processes.;
NCIt note : XCL1 is expressed (0.8-kb mRNA) in activated CD8 T cells, in spleen, thymus, small
intestine, lung, prostate, and ovarian tissues. XCL1 differs from XCL2 by only 2 amino
acids; XCL1 encodes Asp7, Lys8 (mature protein) instead of His, Arg as in XCL2. XCL1
is chemotactic for CD4 and CD8 T cells, but not for monocytes or neutrophils, and
induces increased intracellular calcium in peripheral lymphocytes; XCL1 induces migration
of cells expressing XCR1.;
GenBank Accession Number : NM_002995;
Origin ID : C50973;
UMLS CUI : C1710684;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
