C-X-C Chemokine Receptor Type 6

Preferred Label : C-X-C Chemokine Receptor Type 6;

NCIt synonyms : CXCR-6; BONZO; G Protein-Coupled Receptor Bonzo; CXC-R6; STRL33; G Protein-Coupled Receptor STRL33; G Protein-Coupled Receptor TYMSTR; TYMSTR; Chemokine (C-X-C Motif) Receptor 6; C-X-C Motif Chemokine Receptor-6; CDw186; G-Protein Coupled Receptor STRL33; CD186 Antigen; G-Protein Coupled Receptor Bonzo;

NCIt definition : C-X-C chemokine receptor type 6 (342 aa, 39 kDa) is encoded by the human CXCR6 gene. This protein plays a role in chemokine-mediated signaling.;

NCIt note : Expressed in spleen, thymus, small intestine, activated T cells, peripheral blood leukocytes, prostate, colon, and placenta by human CXCR6 Gene (GPCR1 Family), 342-aa 39-kD integral membrane protein Chemokine (C-X-C Motif) Receptor 6 (CXCL16 ligand) appears to function in interactions between dendritic cells and T cells, in regulating T-cell migration, and in trafficking of effector T cells mediating type-1 inflammation. CXCR6 is a coreceptor for some strains of HIV.;

Details

Origin ID

C28748;

UMLS CUI

C1332653;

OMIM relation
- Chemokine, cxc motif, receptor 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CXCR6 protein, human [MeSH Supplementary Concept]
- CXCR6 protein, human [MeSH concept]
gene_encodes_gene_product
- CXCR6 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Defense Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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