C-C Chemokine Receptor Type 4

Preferred Label : C-C Chemokine Receptor Type 4;

NCIt synonyms : K5-5; CCR-4; CD194 Antigen; CC Chemokine Receptor 4; CCR4; CC-CKR-4; C-C CKR-4;

NCIt definition : C-C chemokine receptor type 4 (360 aa, 41 kDa) is encoded by the human CCR4 gene. This protein is involved in leukocyte chemotaxis.;

NCIt note : C-C chemokine receptor type 4 (CCR4) binds and responds to a variety of C-C chemokines, including MIP-1, CKLF, MDC (CCL22), RANTES (CCL5), TARC (CCL17) and MCP-1 (CCL2). CCR4 is a coreceptor for some isolates of human immunodeficiency virus-2 (HIV-2). (EntrezGene and UniProt);

Details

Origin ID

C129067;

UMLS CUI

C4284283;

Automatic exact mappings (from CISMeF team)
- CC cytokine receptor-4 [MeSH Supplementary Concept]
- Carbon catabolite repression 4-like [OMIM gene]
- Ccr4-not transcription complex, subunit 6 [OMIM gene]
- Chemokine, CC motif, receptor 4 [OMIM gene]
- receptors, ccr4 [MeSH Descriptor]
OMIM relation
- Chemokine, CC motif, receptor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CCR4 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Thymic Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Mogamulizumab [NCIt concept]
- Tivumecirnon [NCIt concept]

Keyword's position in hierarchy(ies) :

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