NCIt definition : An orally available, small molecule antagonist of C-C chemokine receptor type 4 (CCR4)
with potential immunomodulatory and antineoplastic activities. Upon oral administration,
tivumecirnon inhibits the binding of CCR4 to its signaling molecules, thereby blocking
the recruitment of regulatory T-cells (Tregs) to the tumor microenvironment (TME).
This may abrogate the immunosuppressive effects of Tregs and promote an effective
anti-tumor immune response. CCR4, a chemokine receptor normally expressed on circulating
and tissue-resident T-cells, is highly expressed on circulating Tregs and is associated
with poor prognosis in certain cancers.;
Semantic type(s)