Preferred Label : Tivumecirnon;
NCIt synonyms : CCR4 Inhibitor FLX475;
NCIt definition : An orally available, small molecule antagonist of C-C chemokine receptor type 4 (CCR4)
with potential immunomodulatory and antineoplastic activities. Upon oral administration,
tivumecirnon inhibits the binding of CCR4 to its signaling molecules, thereby blocking
the recruitment of regulatory T-cells (Tregs) to the tumor microenvironment (TME).
This may abrogate the immunosuppressive effects of Tregs and promote an effective
anti-tumor immune response. CCR4, a chemokine receptor normally expressed on circulating
and tissue-resident T-cells, is highly expressed on circulating Tregs and is associated
with poor prognosis in certain cancers.;
UNII : R1T69T65FJ;
CAS number : 2174938-78-2;
Molecule name : FLX-475; FLX 475;
NCI Metathesaurus CUI : CL936884;
Origin ID : C157240;
UMLS CUI : C5854834;
Semantic type(s)
- concept_is_in_subset
- has_target
