C-C Chemokine Receptor Type 8

Preferred Label : C-C Chemokine Receptor Type 8;

NCIt synonyms : CKR-L1; TER1; Chemokine (C-C) Receptor 8; CMKBRL2; CC Chemokine Receptor CHEMR1; CKRL1; CY6; CMKBR8; CCR8; GPR-CY6; CCR-8; CDw198; C-C CKR-8; CDw198 Antigen; CC-CKR-8; Chemokine Receptor-Like 1; C-C Motif Chemokine Receptor-8; GPRCY6;

NCIt definition : C-C chemokine receptor type 8 (355 aa, 41 kDa) is encoded by the human CCR8 gene. This protein is involved in chemokine signaling.;

NCIt note : Chemokine (C-C Motif) Receptor 8, encoded by the CCR8 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed preferentially in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) are ligands of this receptor. This receptor and its ligands regulate monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues.;

Details

Origin ID

C25779;

UMLS CUI

C1307911;

OMIM relation
- Chemokine, CC motif, receptor 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CCR8 protein, human [MeSH concept]
- CCR8 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CCR8 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-CCR8 Monoclonal Antibody BAY3375968 [NCIt concept]
- Anti-CCR8 Monoclonal Antibody BMS-986340 [NCIt concept]
- Anti-CCR8 Monoclonal Antibody CM369 [NCIt concept]
- Anti-CCR8 Monoclonal Antibody GS-1811 [NCIt concept]
- Anti-CCR8 Monoclonal Antibody LM-108 [NCIt concept]
- Anti-CCR8 Monoclonal Antibody S-531011 [NCIt concept]
- Anti-CCR8 Monoclonal Antibody SRF114 [NCIt concept]
- Anti-CCR8 Monoclonal Antibody ZL-1218 [NCIt concept]
- CCR8 Inhibitor IPG7236 [NCIt concept]

Keyword's position in hierarchy(ies) :

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