Preferred Label : CCR8 Inhibitor IPG7236;
NCIt definition : An orally bioavailable inhibitor of C-C-chemokine receptor 8 (CCR8), with potential
immunomodulating and antineoplastic activities. Upon oral administration, CCR8 inhibitor
IPG7236 targets, binds to and blocks the activity of CCR8 on CCR8-positive tumor-infiltrating
regulatory T-cells (Tregs) in the tumor microenvironment (TME) and prevents chemokine
ligand 1 (CCL1)-CCR8-mediated signaling. This may reactivate antitumor immune responses.
CCR8 is specifically expressed by tumor-infiltrating Tregs in multiple types of cancer
and plays a key role in immunosuppression, proliferation, resistance, migration and
angiogenesis. High expression is correlated with poor prognosis.;
Molecule name : IPG7-236; IPG 7236;
NCI Metathesaurus CUI : CL1773931;
Origin ID : C185595;
UMLS CUI : C5667008;
Semantic type(s)
- concept_is_in_subset
- has_target
