Preferred Label : Anti-CCR8 Monoclonal Antibody RO7502175;
NCIt synonyms : Anti-C-C Motif Chemokine Receptor 8 Monoclonal Antibody RO7502175;
NCIt definition : A humanized immunoglobulin G1 (IgG1) afucosylated monoclonal antibody directed against
C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic
activities. Upon administration, anti-CCR8 monoclonal antibody RO7502175 targets and
binds to the N-terminus of CCR8 on CCR8-positive, immunosuppressive tumor-infiltrating
T regulatory (TITR) cells in the tumor microenvironment (TME). This depletes CCR8-positive
TITR cells via antibody-dependent cell-mediated cytotoxicity (ADCC), which may reverse
the suppression of CD8 effector T cells and reactivate antitumor immune responses.
CCR8 is specifically expressed by TITR cells in multiple types of cancer and plays
a key role in immunosuppression.;
Molecule name : RO-7502175; RO 7502175;
NCI Metathesaurus CUI : CL1928370;
Origin ID : C205681;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
