NCIt definition : A monoclonal antibody against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating
and antineoplastic activities. Upon administration, cafelkibart targets, binds to
and blocks the activity of CCR8 on CCR8-positive tumor-infiltrating regulatory T-cells
(Tregs) in the tumor microenvironment (TME) and prevents chemokine ligand 1 (CCL1)-CCR8-mediated
signaling. This may reactivate antitumor immune responses. CCR8 is specifically expressed
by tumor-infiltrating Tregs in multiple types of cancer and plays a key role in immunosuppression.
High expression is correlated with poor prognosis.;
Semantic type(s)