Preferred Label : Anti-CCR8 Monoclonal Antibody HC006;
NCIt synonyms : Anti-C-C-chemokine Receptor 8 Monoclonal Antibody HC006; Anti-C-C Motif Chemokine Receptor 8 Monoclonal Antibody HC006;
NCIt definition : A monoclonal antibody directed against human C-C motif chemokine receptor 8 (CCR8),
with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CCR8 monoclonal antibody HC006 targets and binds to CCR8 on CCR8-positive, immunosuppressive
tumor-infiltrating T regulatory (TITR) cells in the tumor microenvironment (TME).
This depletes CCR8-positive TITR cells via antibody-dependent cell-mediated cytotoxicity
(ADCC), which may reverse the suppression of CD8 effector T-cells and reactivate
antitumor immune responses. CCR8 is specifically expressed by TITR cells in multiple
types of cancer and plays a key role in immunosuppression.;
Molecule name : HC-006; HC 006;
Origin ID : C212060;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
