Preferred Label : Anti-CCR8 Monoclonal Antibody CM369;
NCIt synonyms : Anti-CCR8 Monoclonal Antibody ICP-B05;
NCIt definition : A monoclonal antibody against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating
and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody
CM369 targets and binds to CCR8 on CCR8-positive tumor-infiltrating regulatory T-cells
(Tregs) in the tumor microenvironment (TME), and depletes CCR8-positive tumor-infiltrating
Tregs via antibody-dependent cellular cytotoxicity (ADCC). This may reactivate antitumor
immune responses. CCR8 is specifically expressed by tumor-infiltrating Tregs in multiple
types of cancer and plays a key role in immunosuppression.;
Molecule name : ICP B05; CM-369; CM 369; ICP-B05;
NCI Metathesaurus CUI : CL1907031;
Origin ID : C200197;
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target