Preferred Label : Anti-CCR8 Monoclonal Antibody SRF114;
NCIt definition : A human immunoglobulin G1 (IgG1) afucosylated monoclonal antibody against C-C-chemokine
receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities.
Upon administration, anti-CCR8 monoclonal antibody SRF114 targets and binds to CCR8
on CCR8-positive tumor-infiltrating regulatory T-cells (Tregs) in the tumor microenvironment
(TME), and depletes CCR8-positive tumor-infiltrating Tregs via antibody-dependent
cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP).
This may reactivate antitumor immune responses. CCR8 is specifically expressed by
tumor-infiltrating Tregs in multiple types of cancer and plays a key role in immunosuppression.;
Molecule name : SRF-114; SRF 114;
NCI Metathesaurus CUI : CL1905853;
Origin ID : C198695;
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- concept_is_in_subset
- has_target