Preferred Label : Anti-CCR8 Monoclonal Antibody ZL-1218;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody against C-C-chemokine receptor
8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CCR8 monoclonal antibody ZL-1218 targets and binds to CCR8 on CCR8-positive tumor-infiltrating
regulatory T-cells (Tregs) in the tumor microenvironment (TME), and depletes CCR8-positive
tumor-infiltrating Tregs via antibody-dependent cellular cytotoxicity (ADCC). This
may reactivate antitumor immune responses. CCR8 is specifically expressed by tumor-infiltrating
Tregs in multiple types of cancer and plays a key role in immunosuppression.;
Molecule name : ZL 1218; ZL-1218;
NCI Metathesaurus CUI : CL1907334;
Origin ID : C200059;
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- concept_is_in_subset
- has_target