Preferred Label : Anti-CCR8 Monoclonal Antibody ABBV-514;
NCIt synonyms : Anti-C-C Motif Chemokine Receptor 8 Monoclonal Antibody ABBV-514; Anti-C-C-chemokine Receptor 8 Monoclonal Antibody ABBV-514;
NCIt definition : An afucosylated monoclonal antibody directed against human C-C motif chemokine receptor
8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CCR8 monoclonal antibody ABBV-514 targets and binds to CCR8 on CCR8-positive,
immunosuppressive tumor-infiltrating T regulatory (TITR) cells in the tumor microenvironment
(TME). This depletes CCR8-positive TITR cells via antibody-dependent cell-mediated
cytotoxicity (ADCC), which may reverse the suppression of CD8 effector T-cells and
reactivate antitumor immune responses. CCR8 is specifically expressed by TITR cells
in multiple types of cancer and plays a key role in immunosuppression.;
Molecule name : ABBV 514; ABBV-514;
Origin ID : C213671;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
