NCIt definition : A human immunoglobulin G1 (IgG1) afucosylated monoclonal antibody against C-C-chemokine
receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities.
Upon administration, lanerkitug targets, binds to and blocks the activity of CCR8
on CCR8-positive tumor-infiltrating regulatory T-cells (Tregs) in the tumor microenvironment
(TME) and prevents chemokine ligand 1 (CCL1)-CCR8-mediated signaling. Lanerkitug eliminates
CCR8-positive Tregs via the induction of Fc-mediated antibody-dependent cell-mediated
cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP), thereby depleting
CCR8-positive Tregs. This may reactivate antitumor immune responses. CCR8 is specifically
expressed on activated tumor-infiltrating Tregs in multiple types of cancer and plays
a key role in immunosuppression. High expression is correlated with poor prognosis.;
Semantic type(s)