C-C Motif Chemokine 4

Preferred Label : C-C Motif Chemokine 4;

NCIt synonyms : Small Inducible Cytokine A4; AT744.1; MIP-1B; Human Macrophage Inflammatory Protein-1 Beta; SIS-Gamma; MIP-1 Beta; LAG1; CCL4; MIP1B; ACT2; SCYA4; PAT 744; C-C Motif Chemokine Ligand-4; LAG-1; Macrophage Inflammatory Protein 1-Beta; HC21; G-26 T-Lymphocyte-Secreted Protein; Lymphocyte Activation Gene 1 Protein; MIP-1-Beta(1-69); Protein H400; T-Cell Activation Protein 2; MIP-1-Beta; Small-Inducible Cytokine A4; ACT-2; Secreted Protein G-26;

NCIt definition : C-C motif chemokine 4 (92 aa, 10 kDa) is encoded by the human CCL4 gene. This protein is involved in both the regulation of neutrophil and monocyte chemotaxis and the inhibition of HIV binding to C-C chemokine receptor type 5.;

NCIt note : C-C motif chemokine 4 is processed to form MIP-1-beta(3-69). The active form of the chemokine is either a homodimer or a heterodimer comprised of MIP-1-alpha(4-69) and MIP-1-beta(3-69). (UniProt); MIP-1 beta is induced rapidly after T-cell activation with phytohemagglutinin, B-cell activation with Staphylococcus aureus, and monocyte activation with lipopolysaccharide.;

Details

Origin ID

C20477;

UMLS CUI

C1429582;

Automatic exact mappings (from CISMeF team)
- 3'-acetyl-3,5-diiodothyronine [MeSH Supplementary Concept]
- Chemokine, CC motif, ligand 4 [OMIM gene]
- Chemokine, CC motif, ligand 4-like 1 [OMIM gene]
- carbon tetrachloride [MeSH Descriptor]
- ceramide synthase 1 [ORDO Gene]
- chemokine ccl4 [MeSH Descriptor]
OMIM relation
- Chemokine, CC motif, ligand 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CCL4 protein, human [MeSH concept]
- CCL4 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CC Cytokine Gene [NCIt concept]
- CCL4 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Macrophage Inflammatory Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- CCR5 Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antibacterial Response [NCIt concept]
- Antiviral Response [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]

Keyword's position in hierarchy(ies) :

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