Fractalkine - CISMeF

Preferred Label : Fractalkine;

NCIt synonyms : Chemokine (C-X3-C Motif) Ligand 1; Small Inducible Cytokine D1; CX3CL1; Neurotactin; CX3C Membrane-Anchored Chemokine; Small Inducible Cytokine-D1; C-X3-C Motif Chemokine 1; Small-Inducible Cytokine D1;

NCIt definition : Fractalkine (397 aa, 42 kDa) is encoded by the human CX3CL1 gene. This protein is involved in chemotaxis of T-cells and monocytes.;

NCIt note : Unlike other known chemokines, fractalkine is a type 1 membrane protein with a signal peptide, a chemokine domain, a stalk region containing 17 degenerate mucin-like repeats, a transmembrane segment and a cytoplasmic domain. The extracellular domain of fractalkine is released into the supernatants of transfected cells as a 95 kDa glycoprotein, possibly by proteolysis at the dibasic cleavage site proximal to the membrane, to generate soluble fractalkine.;

Details

Origin ID

C20489;

UMLS CUI

C1741764;

Currated CISMeF NLP mapping
- chemokine cx3cl1 [MeSH Descriptor]
OMIM relation
- Chemokine, cx3c motif, ligand 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CX3CL1 protein, human [MeSH concept]
- CX3CL1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CX3CL1 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]

Keyword's position in hierarchy(ies) :

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