Preferred Label : CX3C Chemokine Receptor 1;
NCIt synonyms : G-Protein Coupled Receptor Family 1; Beta Chemokine Receptor-Like 1; C-X3-C CKR-1; CX3CR1; G Protein-Coupled Receptor V28; Chemokine (C-C) Receptor-Like 1; Fractalkine Receptor; G Protein-Coupled Receptor 13; CX3CR1 Protein; Chemokine (C-X3-C Motif) Receptor 1; Fractalkine Receptor CX3CR1; Chemokine, CX3C Motif, Receptor 1; CMK-BRL-1; CMKBLR1; V28; G-Protein Coupled Receptor 13; CMK-BRL1;
NCIt definition : CX3C chemokine receptor 1 (355 aa, 40 kDa) is encoded by the human CX3CR1 gene. This
protein plays a role in cell adhesion, chemotaxis, cell defense response and signal
transduction.;
NCIt note : Up-regulated by chronic inflammation and encoded by human CX3CR1 Gene (CCR Family,
Rhodopsin Family), 355-amino acid 40.4-kD high-affinity Fractalkine Receptor is a
seven transmembrane protein expressed in brain, peripheral blood leukocytes, and spleen
as a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and
adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration
and contains common GPCR features. Tyrosine sulfation enhances fractalkine-induced
cell adhesion. Sharing the CX3C motif, RSV G glycoprotein can use CX3CR1 as a receptor.
CX3CR1 may be an HIV envelope protein co-receptor with CD4. Homozygous CX3CR1 I249/M280
haplotype enhances infection and progression to AIDS. (from LocusLink, Swiss-Prot,
OMIM);
Origin ID : C26209;
UMLS CUI : C1143767;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
