Preferred Label : Autologous Anti-ROR1 CAR-mbIL15-Safety Switch/Intrinsic PD-1 Blockade T-cells PRGN-3007;
NCIt synonyms : Autologous Anti-ROR1 CAR T-cells PRGN-3007; UltraCAR-T Cells PRGN-3007;
NCIt definition : A preparation of autologous T-lymphocytes engineered to express, using a single non-viral
multicistronic transposon plasmid, a chimeric antigen receptor (CAR) targeting the
receptor tyrosine kinase-like orphan receptor 1 (ROR1), membrane-bound IL-15 (mbIL15),
a kill switch and an intrinsic programmed death 1 (PD-1; PDCD1; CD279; programmed
cell death-1) checkpoint blockade, with potential immunomodulatory and antineoplastic
activities. After isolation, non-viral gene transfer, and expansion in culture, the
autologous anti-ROR1 CAR-mbIL15-safety switch/intrinsic PD-1 blockade T-cells PRGN-3007
are reintroduced into the patient and are directed to tumor cells expressing ROR1,
which may result in a selective toxicity against, and lysis of ROR1-expressing tumor
cells. ROR1 is expressed during embryogenesis and upregulated in certain tumor types
with minimal expression in healthy adult tissues. High levels of ROR1 expression often
correlate with poor prognosis. PD-1, an immune checkpoint receptor expressed on T-cells,
plays a key role in tumor immune evasion by binding to its ligand programmed death
ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand
1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling
is halted which may decrease T-cell exhaustion and may enhance T-cell activity against
ROR1-expressing tumor cells. mbIL15 enhances T-cell expansion and persistence through
sustained IL-15 signaling. The kill switch allows for improved safety as it can promote
selective elimination of the CAR-T cells upon treatment with the kill switch activator
antibody.;
Molecule name : PRGN 3007; PRGN-3007;
NCI Metathesaurus CUI : CL1912565;
Origin ID : C192220;
UMLS CUI : C5784990;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
