Autologous Anti-ROR1 CAR-T Cells BMS-986403

Preferred Label : Autologous Anti-ROR1 CAR-T Cells BMS-986403;

NCIt synonyms : Autologous ROR1-targeted CAR T Cells BMS-986403;

NCIt definition : A preparation of autologous T-lymphocytes genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, expansion and reintroduction into the patient, the autologous anti-ROR1 CAR-T cells BMS-986403 are directed to, bind to, and induce selective toxicity in tumor cells expressing ROR1. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in various hematological and solid malignancies. It plays key roles in tumor cell proliferation and survival.;

Molecule name : BMS 986403; BMS-986403;

NCI Metathesaurus CUI : CL1905604;

Details

Origin ID

C192143;

UMLS CUI

C5784931;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tyrosine-Protein Kinase Transmembrane Receptor ROR1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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