" /> Axicabtagene Ciloleucel - CISMeF





Preferred Label : Axicabtagene Ciloleucel;

NCIt synonyms : KTE-C19 CAR; Axi-cel; Axicel;

NCIt definition : A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been transduced with a gammaretoviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3 zeta), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion and re-introduction of axicabtagene ciloleucel into the patient, these cells bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen that is expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex; it regulates both the assembly and cell surface expression of TCR complexes. CD28 is essential for CD4 T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development.;

UNII : U2I8T43Y7R;

Drug name : Yescarta;

Molecule name : KTE-C19; KTE C19;

Codes from synonyms : 54;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.