Preferred Label : Autologous KRAS Mutant-specific TCRs Gene Engineered PBLs;
NCIt synonyms : Autologous Anti-KRAS Mutants TCRs-transduced PBLs; Autologous KRAS TCR-transduced PBLs; Autologous Anti-KRAS Mutants TCR-transduced PBLs;
NCIt definition : A preparation of autologous peripheral blood lymphocytes (PBLs) that have been genetically
modified to express T-cell receptors (TCRs) specific for K-RAS (KRAS) mutations, with
potential immunomodulating and antineoplastic activities. Upon isolation, transduction,
expansion ex vivo and re-introduction into the patient, the autologous KRAS mutant-specific
TCRs gene engineered PBLs target and bind to KRAS mutants-expressing tumor cells,
resulting in a cytotoxic T-lymphocyte (CTL)-mediated killing of KRAS mutants-expressing
tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role
in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive
signal transduction leading to tumor cell proliferation, invasion, and metastasis.;
NCI Metathesaurus CUI : CL1926756;
Origin ID : C204252;
UMLS CUI : C5909648;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
