Autologous Anti-CD19 CAR Vector-transduced T Cells pCAR-19B

Preferred Label : Autologous Anti-CD19 CAR Vector-transduced T Cells pCAR-19B;

NCIt synonyms : pCAR-19B Cells; Anti-CD19 CAR T Cells pCAR-19B;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation (CD) 19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR vector-transduced T-cells pCAR-19B specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.;

Molecule name : pCAR-19B;

NCI Metathesaurus CUI : CL1663475;

Details

Origin ID

C180824;

UMLS CUI

C5556648;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD19 [NCIt concept]

Keyword's position in hierarchy(ies) :

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