" /> ICT-121 Dendritic Cell Vaccine - CISMeF





Preferred Label : ICT-121 Dendritic Cell Vaccine;

NCIt synonyms : ICT-121 DC Vaccine; CD133 Peptides-pulsed Autologous DC Vaccine; CD133 Peptides-pulsed Autologous Dendritic Cell Vaccine;

NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with purified peptides derived from the tumor-associated antigen (TAA) CD133, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, monocytes are differentiated into DCs and are mixed with the CD133 peptides. Upon intradermal re-administration of the ICT-121 DC vaccine, the DCs present the CD133 peptides to the immune system, which stimulates the immune system to induce a specific cytotoxic T-lymphocyte (CTL) response against CD133-expressing tumor cells and leads to tumor cell lysis. CD133 is overexpressed on various types of cancer cells; its overexpression is correlated with increased resistance to chemotherapy.;

Molecule name : ICT-121;

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12/05/2024


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