" /> Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1 - CISMeF





Preferred Label : Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1;

NCIt synonyms : Autologous ET1402L1-CAR T Cells; Autologous T-cells Transduced with ET1402L1-CAR; Autologous AFP-CAR-transduced T-cells ET1402L1; ET1402L1-CAR T-cells; Autologous ET1402L1-CAR T-cells; Autologous AFP-CAR T-cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a human monoclonal antibody specific for an immunogenic human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) epitope, AFP158-166, complexed with human leukocyte antigen (HLA)-A*02:01 (HLA-A*0201/AFP), fused to the co-stimulatory domains of CD28 and CD3zeta, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-HLA-A*0201/AFP CAR T-cells ET1402L1 specifically recognize and selectively bind to the AFP158-166 peptide presented by HLA-A*0201. Upon binding to the AFP-MHC complex, the T-cells release cytokines and induce selective toxicity in HLA-A*0201/AFP-positive tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed in adult tissues, is overexpressed in certain tumors of endodermal origin and plays a key role in tumor cell proliferation and survival. AFP is processed into peptides and presented by class I major histocompatibility complexes (MHCs) on the surface of tumor cells.;

NCI Metathesaurus CUI : CL562702;

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11/05/2025


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