" /> Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19 - CISMeF





Preferred Label : Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19;

NCIt synonyms : Autologous Anti-CD19 CAR-T Cells CNCT19;

NCIt definition : A preparation of autologous T-lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19 target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.;

Molecule name : CNCT-19; CNCT 19;

NCI Metathesaurus CUI : CL1412856;

Details


You can consult :


Nous contacter.
11/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.