NCIt synonyms : Autologous CD19-targeted CAR T-cells CC-97540; Autologous CD19-targeted NEX-T CAR T Cells CC-97540; Autologous CD19-targeted CAR T Cells CC-97540;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA)
CD19, with potential immunostimulating and antineoplastic activities. Upon administration,
zolacabtagene autoleucel specifically target and bind to CD19-expressing tumor cells.
This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor
cells and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific
cell surface antigen overexpressed in B-cell lineage tumors.;