" /> HPV 16 E7 Antigen-expressing Lactobacillis casei Vaccine BLS-ILB-E710c - CISMeF





Preferred Label : HPV 16 E7 Antigen-expressing Lactobacillis casei Vaccine BLS-ILB-E710c;

NCIt synonyms : Attenuated Live Listeria Encoding HPV 16 E7 Vaccine; LacE7 Vaccine; L. casei-E7 BLS_ILB_E710c; L.casei-PgsA-E7;

NCIt definition : An orally available Lactobacillis casei (L. casei)-based vaccine expressing the human papillomavirus (HPV) type 16 isoform E7 protein linked to the poly-gamma-glutamate synthetase complex gene pgsA, with potential immunostimulating activity. Upon oral administration, the expressed HPV 16 E7 may stimulate the immune system to mount a mucosal cytotoxic T-lymphocyte (CTL) response against HPV 16 E7-expressing tumor cells. The poly-glutamic acid synthetase PgsA from Bacillus subtilis acts as an anchoring motif that facilitates the expression of the HPV antigen protein on the surface of the bacteria. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in various viral-related cancers.;

Molecule name : BLS-ILS-E710c; BLS-ILB-E710c;

NCI Metathesaurus CUI : CL474114;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
12/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.