SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte

Preferred Label : SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte;

NCIt definition : A population of tumor-infiltrating lymphocytes (TILs) harvested from a patient and transduced with a retroviral vector encoding the gene for interleukin-2 (IL-2). TILs require IL-2 to sustain them when they are transferred back to the patient. By inserting the IL-2 gene into TILs in vitro so that TILs express IL-2 continuously it is possible to provide TIL-sustaining IL-2 in vivo specifically at the site of lymphocyte infiltration, thereby avoiding the toxicity associated with the systemic administration of IL-2. (NCI04);

NSC code : 722760;

Details

Origin ID

C38118;

UMLS CUI

C1519129;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
has_target
- Interleukin-2 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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