NCIt definition : A subset of therapeutic autologous T-lymphocytes that express a T-cell receptor (TCR)
composed of one gamma chain and one delta chain, with potential immunomodulating and
antineoplastic activities. Upon administration of the therapeutic gamma delta T-lymphocytes,
these cells secrete interferon-gamma (IFN-g), and exert direct killing of tumor cells.
In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte
(CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the
activation of the immune system and do not require major histocompatibility complex
(MHC)-mediated antigen presentation to exert their cytotoxic effect.;