NCIt synonyms : Autologous CD79b-19 CAR T cells; Bivalent CD79b/CD19 Directed CAR T Cells;
NCIt definition : A preparation of autologous T-lymphocytes that are genetically engineered to express
a chimeric antigen receptor (CAR) targeting the two tumor-associated antigens (TAAs)
CD19 and B-cell antigen receptor complex-associated protein beta chain (CD79b; B-cell-specific
glycoprotein B29), with potential immunostimulating and antineoplastic activities.
Upon administration, the autologous anti-CD19/anti-CD79b CAR-expressing bispecific
T-cells are directed to and induce selective toxicity in CD19- and CD79b-expressing
tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all
B-cell lineage malignancies. CD79b, a B cell surface antigen and critical receptor
for successful B cell development, is part of the B cell receptor (BCR) signaling
complex. It is widely expressed in certain subtypes of B cell lymphomas. CD19 and
CD79b are expressed at high levels on tumor cells but not at significant levels on
normal tissues. Targeting two antigens may protect against antigen escape and may
enhance CAR-T cell efficacy.;