NCIt definition : A vaccine consisting of human papillomavirus-derived noninfectious virus-like particles
(VLPs), containing the L1 major capsid protein. Vaccination with HPV 16 L1-VLP results
in increases in T cell-proliferative response to HPV 16 L1-VLP, as well as significant
increases in cytokine (interferon-gamma, interleukin-5 and -10) responses to L1 VLP.
This agent may reduce the incidence of persistent HPV-16 infection, which may be responsible
for half of all cases of cervical cancer including high-grade cervical intraepithelial
neoplasia. (NCI04);