NCIt definition : A cancer vaccine consisting of autologous dendritic cells (DCs) loaded with autologous,
lethally irradiated cancer cells and mixed with the cytokine granulocyte-macrophage
colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic
activities. Upon vaccination, ovapuldencel-T may stimulate the immune system to exert
a cytotoxic T-lymphocyte (CTL) immune response against the repertoire of tumor associated
antigens (TAAs) found in the irradiated cancer cells. GM-CSF enhances the activation
of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes.;