Autologous HBV-specific TCR-expressing T-lymphocytes SCG101

Preferred Label : Autologous HBV-specific TCR-expressing T-lymphocytes SCG101;

NCIt synonyms : Autologous HBV-specific T-cell Receptor-expressing T-lymphocytes SCG101; Autologous HBV-specific TCR-T Cells SCG101;

NCIt definition : A preparation of human autologous T-lymphocytes transduced with a retroviral vector encoding for a T-cell receptor (TCR) specific for HLA-A*02-restricted human hepatitis B virus (HBV) surface antigen (HBsAg) peptide, with potential antineoplastic activity. Upon administration, the autologous HBV-specific TCR-expressing T-lymphocytes SCG101 recognize and bind to HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cells, including those in HBV-related hepatocellular carcinoma (HCC).;

Molecule name : SCG 101; SCG-101;

NCI Metathesaurus CUI : CL1792173;

Details

Origin ID

C187331;

UMLS CUI

C5706400;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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