Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes

Preferred Label : Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes;

NCIt synonyms : Anti-p53 T-Cell Receptor Retroviral Vector-Transduced Peripheral Blood Lymphocytes; Anti-p53 TCR-Transduced PBL; Anti-p53 TCR Retroviral Vector-Transduced PBL; Anti-p53 T Cell Receptor-Transduced Peripheral Blood Lymphocytes;

NCIt definition : Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation.;

Details

Origin ID

C64773;

UMLS CUI

C5552636;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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