" /> Autologous Natural Killer Cell-like CTLs - CISMeF





Preferred Label : Autologous Natural Killer Cell-like CTLs;

NCIt synonyms : Therapeutic iNKT Cells; In Vitro DC-sensitized CTLs; Therapeutic nCTLs; Autologous Natural Killer-like Cytotoxic Lymphocytes; In-vitro DC-sensitized Autologous CTLs; Autologous NK-like CTLs; Autologous nCTLs; Autologous aDC1-induced CTLs; Autologous CTLs Sensitized Ex-vivo with Autologous TAA-loaded alphaDC1; Tumor Neo-antigen-specific nCTLs;

NCIt definition : A preparation of cytotoxic T-lymphocytes (CTLs) that express natural killer (NK)-like features (nCTLs), with potential immunomodulating and antineoplastic activities. The nCTLs are derived from autologous lymphocytes that have been in vitro exposed to autologous alpha-type-1 polarized dendritic cells that are pulsed with specific autologous tumor-associated antigens (TAAs); the nCTLs are subsequently expanded in the presence of the cytokine human interleukin-2 (IL-2). The generated nCTLs are potent CTLs that produce high amounts of granzyme B and perforin, and interferon-gamma (IFNg) with high killer activity and tumor-homing potential. Upon infusion of the autologous nCTLs, these cells specifically recognize the TAAs on the tumor cells, then bind to and directly lyse tumor cells.;

NCI Metathesaurus CUI : CL563005;

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15/05/2024


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