Ex Vivo-activated Autologous Lymph Node Lymphocytes

Preferred Label : Ex Vivo-activated Autologous Lymph Node Lymphocytes;

NCIt synonyms : X-ACT; X-ACT Autologous Lymph Node Lymphocytes;

NCIt definition : Autologous human lymph node T-lymphocytes, with potential immunostimulatory and antineoplastic activity. Upon collection of immune cells from the tumor-draining lymph node, the human lymph node lymphocytes are activated with anti-CD3/anti-CD28 microbeads, cultured with recombinant, human interleukin-2 (IL-2), expanded and isolated ex vivo. Upon reintroduction into the patient, the ex vivo-activated autologous lymph node lymphocytes recognize and lyse the tumor cells.;

NCI Metathesaurus CUI : CL472580;

Details

Origin ID

C114985;

UMLS CUI

C3896582;

Automatic exact mappings (from CISMeF team)
- X-active-specific noncoding transcript [OMIM gene]
Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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